國立成功大學生命科學系

首頁

彭怡禎 助理教授

 

王浩文助理教授

  助理教授

  電話: +886-6-275-7575 ext. 65532

  email: ipeng@mail.ncku.edu.tw

             <English Version>       

實驗室網頁:Web

研究專長
: 
分子代謝醫學、營養代謝與基因調控、癌症生物學

研究方向:
 
脂質代謝的分子調控機制

脂肪組織為許多生理代謝途徑的樞紐,並扮演著維持體內能量恆定的角色。脂質是否會堆積於脂肪細胞內,取決於脂質合成與分解兩者間的平衡。Acetyl-CoA carboxylase (ACC1/ACC2)為催化脂肪酸合成第一步驟的酵素,是決定脂質合成速率的最主要因子。AMP-activated protein kinase (AMPK)為一代謝感應中樞,會受到禁食、運動及限制卡路里攝取等刺激的活化,來增加細胞內脂質及葡萄糖的代謝。AMPK可磷酸化ACC1/ACC2並抑制其活性。除了直接改變脂質合成相關酵素的活性外,脂質合成也能夠透過轉譯調控的方式來調節。本實驗室研究致力於找出脂質代謝的分子調控機制及如何降低脂質堆積的方法,以解決肥胖及因肥胖而衍生出的相關疾病。

 癌症代謝及表觀遺傳學

癌症可視為一種代謝異常的疾病。目前已知癌細胞會比正常的細胞消耗更多的葡萄糖的及產生乳酸 (Warburg effect),並增加細胞內脂質及蛋白質的合成,及增加麩醯胺酸 (glutamine)的消耗,以利癌細胞的增生。Myc為一常見的致癌基因蛋白,在很多種癌細胞中皆被大量表達,並調控許多重要代謝酵素的生成。本實驗室研究發現Myc可透過表觀遺傳學的方式來調控基因啟動子甲基化的情形,並促進glutamine synthetase的表現。因此本實驗室的研究目標為找出促使癌細胞異常生長的各種代謝途徑,並探討其分子調控機制,以利抗癌藥物的研發。


經歷

經歷 年份
助理教授, 國立成功大學生命科學系 2014
博士後研究員,美國紐約石溪大學 2012
博士後研究員,美國加州大學河濱分校 2011

學歷

博士 生物化學與分子生物學所美國加州大學河濱分校
碩士 農業化學所,國立臺灣大學
學士,農業化學系,國立臺灣大學

 

論文著述:

論文(click)

A. 期刊論文

  1. Alex J. Bott (co-first author), I-Chen Peng (co-first author), Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokowski, Wenyun Lu, Ji-An Pan, Scott Powers, Joshua Rabinowitz, Maria Hatzoglou, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. 2015. Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism. 22(6): 1068-1077. 

  2. Yu-Ting Hung, Chi-Te Liu, I-Chen Peng, Chin Hsu, Roch-Chui Yu, Kuan-Chen Cheng. 2015. The implementation of a Hazard Analysis and Critical Control Point management system in a peanut butter ice cream plant. J Food Drug Anal. 23(3):509-515. 

  3. Brendan Gongol, Traci Marin, I-Chen Peng, Brian Woo, Stephanie King, Marcy Martin, Wei Sun, Shu Chien, and John Y-J. Shyy. 2013. AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 110(8):3161-3166. 

  4. I-Chen Peng, Kai-Yin Lo, Chun-Hua Hsu, and Chia-Yin Lee. 2012. Increasing the storage and oxidation stabilities of N-acyl-D-amino acid amidohydrolase by site-directed mutagenesis of critical methionine residues. Process Biochemistry. 47:1785-1790. 

  5. I-Chen Peng, Zhen Chen, Wei Sun, Ying-Shiuan Li, Traci LaNai Marin, Pang-Hung Hsu, Mei-I Su, Xiaopei Cui, Songqin Pan, Christian Y. Lytle, David A. Johnson, Frank Blaeser, Talal Chatila, and John Y-J. Shyy. 2012. Glucagon regulates ACC activity in adipocytes through the CaMKKb/AMPK pathway. Am J Physiol Endocrinol Metab. 302(12):E1560-1568. 

  6. Zhen Chen (co-first author), I-Chen Peng (co-first author), Xiaopei Cui, Yi-Shuan Li, Shu Chien, and John Y-J. Shyy. 2010. Shear Stress, SIRT1, and Vascular Homeostasis. Proc Natl Acad Sci U S A. 107(22):10268-10273. 

  7. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Yi Fu, Yi Zhu, Kathryn DeFea, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. 2009. AMP-Activated Protein Kinase Functionally Phosphorylates Endothelial Nitric Oxide Synthase Ser633. Circ Res.104:496-505.

 

 

B. 研討會論文
  1. I-Chen Peng. “Myc induces expression of glutamine synthetase through promoter demethylation.” The 5th International Conference and Exihibition on Metabolomics 2016, Osaka, Japan. (Invited Speaker)

  2. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.” The 15th SCBA International Symposium 2015, Academia Sinica, Taipei, Taiwan.

  3. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.”The 8th France-Taiwan Frontiers of Science 2015, Kaohsiung, Taiwan

  4. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Gloria and Mark Snyder Symposium for Cancer Medicine 2014, Stony Brook, New York, USA.

  5. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Molecular Genetics and Microbiology Annual Department Retreat 2013, Port Jefferson, New York, USA.

  6. I-Chen Peng, Zhen Chen, Pang-Hung Hsu, Mei-I Su, Ming-Daw Tsai, and John Y-J. Shyy. “Glucagon Activates the AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Pathway in Adipocytes.” Experimental Biology Meeting 2010, Anaheim, California, USA.

  7. I-Chen Peng and John Y-J. Shyy. “AMP-Activated Protein Kinase Phosphorylates Acetyl-CoA Carboxylase at Ser-79 Responding to Glucagon.” 21st Annual Biochemistry and Molecular Biology Research Symposium 2009, Riverside, California, USA.

  8. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. “Shear Stress Increases the Phosphorylation of eNOS Ser-633 and Level of Sirt1.” The 12th SCBA International Symposium 2009, Academia Sinica, Taipei, Taiwan.

 

 

 

瀏覽數  
將此文章推薦給親友
請輸入此驗證碼