國立成功大學生命科學系

曾淑芬特聘教授

曾淑芬特聘教授  特聘教授

  電話:+886-6-275-7575 ext.65537

  email: stzeng@mail.ncku.edu.tw

   <English Version>

 

研究專長: 神經生物學、幹細胞分化、神經退化疾病

研究方向:本實驗室的長期研究目標是釐清中樞神經系統神經元細胞與神經膠細胞的交互作用在神經發育、神經退化與再生所扮演的角色。研究主題為

(一)、探討發炎分子調控幹細胞分化神經元和膠細胞的機制。

(二)、探討神經膠細胞對於滋養和保護神經元細胞的分子機制。

(三)、探討代謝症候誘發神經發炎與情感障礙的關聯性。

(四)、探討調控幹細胞癌化的分子機制。

 

學歷

博士 生物化學研究所,美國維吉尼亞州立大學醫學院
碩士 生物化學研究所,國立台灣大學醫學院
化學系,國立成功大學 

經歷

經歷 年份
國立成功大學 生命科學系  系主任 2015
國立成功大學 生命科學系特聘 教授 2008
國立成功大學 生命科學系 教授

2005

國立成功大學 生物系 副教授 2002
國立成功大學 生物系 助理教授 2001
台中榮民總醫院 教學研究部 副研究員 1997
UCLA School of MedicineUSA 博士後研究員 1994
國立台灣大學醫學院 生物化學研究所 助教 1988

榮譽與獎勵

榮譽與獎勵 年份
榮任 國立成功大學生命科學系 系主任 2015--迄今
三度榮獲 國立成功大學 特聘教授 2015--迄今
榮獲 國立成功大學 特聘教授 2008--迄今
榮獲 中華民國基礎神經科學頒發青年研究獎 2002
榮獲 國科會甲等獎助 1998
榮獲 美國神經化學學會 Marian W. Kies Award  1995

論文(click)

論文著作:

A. 期刊論文 

1. Liao CK#(co-first author), Fang KM# (co-first author), Chai KM, Wu CH, Ho CH, Yang CS, Tzeng SF* (2016) Depletion of B-cell CLL/lymphoma 11B gene expression represses glioma cell growth. Mol Neurobiol. 2016 Aug;53(6):3528-39.

2. Wang CY, Yang SH, Tzeng SF* (2015, Feb).MicroRNA-145 as One Negative Regulator of Astrogliosis. Glia, 63(2):194-205.

3. Wang CY, Cheng CW, Wang WH, Chen PS, Tzeng SF* (2015) Postnatal Stress Induced by Injection with Valproate Leads to Developing Emotional Disorders Along with Molecular and Cellular Changes in the Hippocampus and Amygdala. Mol Neurobiol. 2015 Dec 11. [Epub ahead of print]

4. Fang KM, Liu JJ, Li CC, Cheng CC, Hsieh YT, Chai KM, Lien YA,Tzeng SF* (2015) Colchicine derivative as a potential anti-glioma compound. J Neurooncol.

          Sep;124(3):403-12.

5. Kit Man Chai, Chih-Yen Wang, Hung-Jiun Liaw, Kuan-Min Fang, Chung-Shi Yang , Shun-Fen Tzeng* (2014) Downregulation of BRCA1-BRCA2-containing Complex Subunit 3 sensitizes glioma cells to Temozolomide. Oncotarget, accepted (17/202; IF, 6.627; ONCOLOGY).

6. Wang CY, Yang SH, Tzeng SF* (2014, Aug). MicroRNA-145 as one negative regulator of astrogliosis. Glia, In press. (35/251; IF, 5.466; NEUROSCIENCES)

7. Su WP, Hsu SH, Wu CK, Chang SB, Lin YJ, Yang WB, Hung JJ, Chiu WT, Tzeng SF, Tseng YL, Chang JY, Su WC, Liaw H* (2014, Aug). Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma. Oncotarget, 30;5(15):6323-37. (17/202; IF, 6.627; ONCOLOGY)

8. Fang KM, Yang CS, Lin TC, Chan TC, Tzeng SF* (2013, Dec). Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells. Neuro-oncology, 16(4):552-66. (18/194; IF, 5.286; CLINICAL NEUROLOGY)

9. Fang KM, Lin TC, Chan TJ, Chang WR, Ma SZ, Tzou BC, Liu JJ, Chiou SH, Yang CS*, Tzeng SF* (2013). Enhanced tumorigenicity of rat glioma cells by overexpression of human CD133 through multiple molecular actions. Glia, 61(9):1402-17. (35/251; IF, 5.466; NEUROSCIENCES)

10. Lu WH, Wang CY, Chen PS, Wang JW, Chuang DM, Yang CS*, Tzeng SF* (2013, May). Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia. Journal of Neuroscience Research, 91:694-705. (141/251; IF, 2.729; NEUROSCIENCES)

11. Fang KM, Liu YY, Lin CH, Fan SS, Tsai CH, Tzeng SF* (2012, Sep). Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMPdependent pathway. Journal of Cellular Biochemistry, 113:3019–3028. (107/291; IF, 3.368; BIOCHEMISTRY & MOLECULAR BIOLOGY)

12.  Chan TJ, Her LS, Liaw HJ, Chen MC, Tzeng SF* (2012, May). Retinoic acid mediates the expression of glutamate transporter-1 in rat astrocytes through genomic RXR action and non-genomic protein kinase C signaling pathway. Journal of Neurochemistry, 121(4):537-550. (63/251; IF, 4.244; NEUROSCIENCES)

13.  Lee JS, Yang CC, Kuo YM, Sze CI, Hsu JY, Huang YH, Tzeng SF, Tsai CL, Chen HH, Jou IM* (2012, Jan). Delayed G-CSF Treatment Promotes Functional Recovery in Rats with Severe Contusive Spinal Cord Injury. Spine (Phila Pa 1976, 37(1):10-17. (15/67; IF, 2.447; ORTHOPEDICS)

14. Fang KM, Wang YL, Huang MC, Sun SH, Cheng H, Tzeng SF* (2011, Feb). Expression of macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in glioma-infiltrating microglia: Involvement of ATP and P2X(7) receptor.. Journal of Neuroscience Research, 89:199-211. (141/251; IF, 2.729; NEUROSCIENCES)

15. Wang CY, Chen JK, Wu YT, Tsai MJ, Shyue SK, Yang CS, Tzeng SF* (2011, Feb). Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury. Journal of Biomedical Science, 18:13-. (49/122; IF, 2.736; MEDICINE, RESEARCH & EXPERIMENTAL)

16. Chen JK, Zhan YJ, Yang CS, Tzeng SF* (2011, Jan). Oxidative stress-induced attenuation of thrombospondin-1 expression in primary rat astrocytes. Journal of Cellular Biochemistry, 112(1):59-70. (107/291; IF, 3.368; BIOCHEMISTRY & MOLECULAR BIOLOGY) NSC 96-2321-B-006-006-MY3.

17. Fang, KM, Chen, JK, Hung SC, Chen MC, Wu YT, Wu, TJ, Lin, HI, Chen CH, Cheng H, Yang, CS, Tzeng SF* (2010, Dec). Effects of combinatorial treatment with pituitary adenylate cyclase activating peptide and human mesenchymal stem cells on spinal cord tissue repair. PLOS One, 5(12):e15299. (8/55; IF, 3.534; MULTIDISCIPLINARY SCIENCES)

18. Sun YT, Lin TS, Tzeng SF, Delpire E, Shen MR* (2010, Oct). Deficiency of electroneutral K+-Cl- cotransporter 3 causes a disruption in impulse propagation along peripheral nerves. Glia, 58(13):1544-52. (35/251; IF, 5.466; NEUROSCIENCES)

19. Su CK, Sun YC*, Tzeng SF, Yang CS, Wang CY, Yang MH (2010, May). In vivo monitoring of the transfer kinetics of trace elements in animal brains with hyphenated inductively coupled plasma mass spectrometry techniques. Mass Spectrometry Reviews, 29(3):392-424. (2/44; IF, 8.053; SPECTROSCOPY)

20. Liu YP, Yang CS, Chen MC, Sun SH, Tzeng SF* (2010, Apr). Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling. Journal of Neurochemistry, 113(1):213-27. (63/251; IF, 4.244; NEUROSCIENCES)

21. Fang KM, Yang CS, Sun SH, Tzeng SF* (2009, Oct). Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X receptor action. Journal of Neurochemistry, 111(5):1225-12237. (63/251; IF, 4.244; NEUROSCIENCES)

22. Jean YH, Chen WF, Sung CS, Duh CY, Huang SY, Lin CS, Tai MH, Tzeng SF, Wen ZH* (2009, Oct). Capnellene, a natural marine compound derived from soft coral, attenuates chronic constriction injury-induced neuropathic pain in rats. British Journal of Pharmacology, 158(3):713-25. (21/254; IF, 4.990; PHARMACOLOGY & PHARMACY)

23. Wang CC, Fang KM, Yang CS, Tzeng SF* (2009, Aug). Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondriamediated mechanism. Journal of Cellular Biochemistry, 107:933-943. (107/291; IF, 3.368; BIOCHEMISTRY & MOLECULAR BIOLOGY)

24. Lee TI, Yang CS, Fang KM, Tzeng SF* (2009, Jan). Role of ciliary neurotrophic factor in microglial phagocytosis. Neurochemical Research, 34(1):109-17. (147/251; IF, 2.551; NEUROSCIENCES)

C. 其他著作

1.  誘發神經分化之方法及組合物. 中華民國專利證書發明第I285219號; 鄭宏志,曾淑芬; 2007/08/00 ~ 2025/06/00

2.  Use of stem cells for inducing neural differentiation; 歐洲 1619244; Henrich Cheng and Shun-Fen Tzeng; 2010/11/00

3.  基礎人體生理學 (Fundamentals of Human Physiology)/Stuart Ira Fox著,曾淑芬譯。麥格羅希爾-高立圖書有限公司(ISBN 978-986-157-592-6; 修訂版 ISBN 978-986-157-819-4).

 

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